Have you ever thought about a series about minions from a group like hydra or aim not the big super powered guys but the cronies of those guys? (Thanks to Stephen Card for the question.)
As much fun as that sounds, I don't have a big interest in writing groups larger than just a few characters. Now, if I were to follow one or two minions around, then we'd be onto something that I'd find interesting to write.
I think the best I've seen done along those lines is the work done with Number 21 and Number 24 on The Venture Bros. I'm afraid I couldn't do it any better than that, no matter how hard I tried.